The FDA has approved several new drugs for lowering cholesterol, including a drug that blocks the enzyme 5-alpha reductase. (AstraZeneca, which is the maker of the drug and AstraZeneca, which is the maker of the drug).
The approval was based on a large-scale study that found that Crestor, an inhibitor of the enzyme that reduces LDL cholesterol levels, is safe and effective in preventing the development of heart disease and lowering blood pressure.
The Food and Drug Administration is looking at the results of a large, two-year, randomized, double-blind, placebo-controlled trial on 5,746 participants. The participants were randomly assigned to receive Crestor or a placebo drug for a period of eight weeks. During the eight weeks, participants were given a lipid-lowering diet, a high-salt diet, or a low-salt diet for a period of six weeks. Then, participants were evaluated by the physician, who prescribed Crestor and another drug called statins. A total of 869 participants were randomized into the treatment arm, the placebo arm and the statin arm for eight weeks. The results showed that Crestor is safe and effective for reducing LDL cholesterol in people who have high blood pressure, heart disease, high blood sugar and other cardiovascular risk factors. (See also “” for more information.)
Other studies have found that Crestor is effective in reducing triglyceride levels, an increase in blood pressure and cholesterol, and lowering the risk of stroke.
In the current study, a combination of Crestor and a statin was also prescribed for patients who have cardiovascular disease and had elevated LDL cholesterol and triglycerides. In the treatment group, the Crestor combination was found to be more effective than the statin. (See “” for more information.)
A study in patients with type 2 diabetes showed that there is no increased risk of death from cardiovascular events after taking the statin, but there was a small increase in the risk of death from heart attacks.
Another study, published in the December 2016 issue of theJournal of the American Medical Association, found that the Crestor treatment is safe and effective in preventing strokes and heart attacks in patients with high blood pressure and high cholesterol.
“The approval of Crestor is important because it has been shown to be safe and effective in lowering blood pressure and improving the health of patients with high cholesterol and high blood pressure,” said Steven Nissen, MD, a cardiologist at Washington University in St. Louis who is not involved in the study.
“The approval of Crestor is important because it has been shown to be safe and effective in lowering blood pressure and improving the health of patients with high cholesterol and high blood pressure,” said Steven Nissen, MD, a cardiologist who is not involved in the study.
“The FDA has not approved any new drugs to treat high blood pressure or heart disease, and therefore, we cannot conclude that these drugs are safe and effective,” said Nissen.
The results are expected to be published in the December 2017 issue of the journal,.
Originally published November 9, 2006.
Photo:Copyright © 2006 by The Canadian Institutes of Health Research
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1. U. S. Government Accountability Office. (2009, May). AstraZeneca’s Crestor clinical trial data report, AstraZeneca Inc. Accessed November 8, 2006.
2. AstraZeneca Canada Inc. (2009, July). Crestor: a clinical trial data database, AstraZeneca Inc.
3. Canadian Institutes of Health Research. (2009, September). Crestor and statin for treating heart disease, Canadian Institute of Health Research, Accessed November 8, 2006.
4. (2011, April). Crestor and diabetes, Canadian Institute of Health Research, Accessed November 8, 2006.
5. Canadian Association of Cardiovascular Research. (2004, December). Crestor: a clinical trial data database, Canadian College of Cardiology, Accessed November 8, 2006.
6. Canadian Society of Health-System Pharmacists. (2007, January 1).
Crestor, also known as rosuvastatin, is an oral medication used primarily in the treatment of cholesterol disorders, including and statin-induced hypercholesterolemia. It belongs to the statin class of drugs, and it is a popular choice for patients who are concerned about the potential side effects associated with statins. While it is generally well-tolerated, it is important to be aware of potential drug interactions that could influence its efficacy or the likelihood of adverse events.
Crestor is a statin primarily used to lower LDL (bad) cholesterol and triglycerides (good) cholesterol. The drug has been shown to reduce the risk of heart attacks, strokes and heart failure by 90-95%. It is also used to lower the risk of certain types of cancers such as prostate cancer, breast cancer and ovarian cancer.
The usual starting dose of Crestor is 40 mg once daily. Depending on how well it works, it can be increased to 80 mg once daily. The dosage can be adjusted based on individual response to the drug, but it is important to follow the prescribed dosage and not to alter it without consultation with your healthcare provider. It is recommended to take the medication at evenly spaced intervals to ensure the best possible outcome.
While Crestor is generally well-tolerated, some patients may experience adverse effects or side effects. It is important to be aware of these risks and to report any unusual symptoms or side effects promptly to your healthcare provider.
Some individuals may experience side effects from taking Crestor, such as headache, nausea and digestive discomfort. These symptoms may indicate a potential adverse reaction to the medication. It is important to note that Crestor can cause side effects such as:
It is important to talk to your healthcare provider about any side effects you are experiencing, including any concerning side effects, especially if you are pregnant or breastfeeding. They will be able to provide personalized advice based on your specific situation and could monitor you closely while you are taking Crestor.
You can purchase Crestor from reputable online pharmacies that offer a prescription service. It is important to choose a reliable source to receive the medication safely and to avoid counterfeit or expired medications. Check for the following steps:
Crestor is primarily used to lower cholesterol and triglycerides in people with high cholesterol or low levels of LDL (bad) cholesterol. It is also used in patients who have experienced adverse reactions to statins. This medication works by blocking the production of cholesterol from the liver and increasing the amount of cholesterol it produces in the bloodstream.
Crestor works by blocking the production of cholesterol in the liver, which is necessary for the body’s cholesterol production. By blocking the production of cholesterol from the liver, Crestor effectively lowers the amount of cholesterol in the bloodstream. This reduction in cholesterol levels helps prevent heart disease, heart attacks and other serious complications in the long run.
Common side effects of Crestor include:
Before taking Crestor, inform your healthcare provider if you have a history of heart disease, high or low blood pressure, or a history of stroke or heart attack.
The first of its kind, the cholesterol-lowering drug Crestor was the first to be introduced in the market. But the world's largest generic drugmaker, known for its high-dose version of the drug's active ingredient, Lipitor, has been accused of overcharging for its sales.
Crestor, sold as Nexium, became the first statin to be approved in the US market by the Food and Drug Administration for the treatment of high cholesterol. In November 2010, AstraZeneca agreed to pay $1.4 billion to settle allegations that its Lipitor had been misbranded as a drug for the treatment of high blood pressure and heart disease.
But as the cost of Crestor, as of this article, rises, the generic drugmaker says the drug was a "statin" that it is unable to beat.
"When this drug is first developed, you have to do a lot of research, but that research has not been done, so it has to be a treatment that will be given to millions of patients around the world for the treatment of diseases that are not necessarily related to the disease itself," said Matthew M. Kastelein, an analyst with the American Association for the Study of Diabetes (AASD). "That is one of the reasons why the Lipitor has become so popular."
The lawsuit alleges that the company has used a number of marketing tactics to increase sales and promote the drug. The lawsuits claim that the company's attempts to push the drug through the market by promoting it through its own website and other channels were misleading, and that it used the drug for marketing without proper research.
The lawsuit alleges that AstraZeneca knew at the beginning of its marketing strategy that the drug was not intended for the treatment of patients with high blood pressure and heart disease and that the company had chosen a treatment for a condition that the FDA had not identified.
The case was investigated by the FDA and the Federal Trade Commission (FTC), and the complaint was filed in March 2012. The suit alleges that AstraZeneca knew the price of Crestor in the first place and that it had used the drug for the treatment of a rare condition called benign prostatic hyperplasia.
The suit also alleges that AstraZeneca was aware of the marketing tactics in the first place and that they had manipulated the price of Crestor, even as the drug's patent was set to expire in December 2010. As a result, the company was able to continue to make sales, but the drug was not marketed and sales dropped.
In the suit, Kastelein sought to have the suit dismissed because the plaintiffs claimed that the companies had "improperly misleading" the FDA and that the plaintiffs' allegations were not true.
Crestor's patent was set to expire in December 2010 and the patent that AstraZeneca had filed with the FDA expired, meaning the generic drug maker was forced to compete with the branded drugmaker. But the FDA has said it will soon approve the drug.
The lawsuit seeks to invalidate AstraZeneca's marketing of Crestor. It claims that the drug had the wrong dose of Crestor, the same dose that the FDA had approved for the treatment of high blood pressure and heart disease.
The lawsuit alleges that the company failed to adequately explain the drug's label and that the FDA did not consider the drug's label sufficient to warn about its adverse effects, including an increase in heart attack symptoms and heart failure.
The lawsuit alleges that AstraZeneca knew at the beginning of its marketing strategy that the drug was not intended for the treatment of high blood pressure and heart disease and that the company had chosen a treatment for a condition that the FDA had not identified.
The lawsuit seeks to invalidate the marketing of Crestor and also seeks to invalidate the FDA's approval of the drug.
The lawsuit claims that the agency did not consider the drug's label sufficient to warn about the increased risk of heart attack and stroke, and that it was only allowed to approve the drug after an independent review by a company spokeswoman.
The lawsuit seeks to invalidate the FDA's approval of the drug and also seeks to invalidate the FDA's approval of Crestor.
CRESTOR 20MG TABLET is used in the management of high blood cholesterol levels. It is prescribed when diet and exercise does not result in adequate results. It contains a medicine called which is an anti-hyperlipidemic agent that works by blocking cholesterol production in the body. It also makes your body eliminate lipids particles from the blood.
By reducing blood cholesterol levels, this medicine is helpful is reducing cardiovascular risks and problems in blood circulation across the body. While taking CRESTOR 20MG TABLET, you must follow a cholesterol-lowering diet, lifestyle changes and regular physical activity as instructed by your doctor to achieve better results.
Before taking CRESTOR 20MG TABLET inform your doctor if you have any lung, liver, kidney or heart problems. You must also inform your doctor if you have diabetes, thyroid problems, or a family history of muscle disorders. Do not take CRESTOR 20MG TABLET if you are pregnant or breastfeeding without consulting your doctor.
CRESTOR 20MG TABLET may increase your blood sugar levels, especially in patients who are diabetic. It may also affect the way your liver works and so your doctor will closely monitor your blood sugar levels and liver functions while undergoing therapy with CRESTOR 20MG TABLET as a precaution.
The most common side effects of taking CRESTOR 20MG TABLET are muscle ache, constipation, stomach pain, dizziness, nausea and headache. Inform your doctor if you experience severe unexplained muscle pain, tenderness or weakness along with fever after taking CRESTOR 20MG TABLET.
How should I take CRESTOR 20MG TABLET? The dose and duration of CRESTOR 20MG TABLET must be determined by your doctor, while taking it.
Stade de France Pharmacy